Mouse Gene Set: ZHANG_BREAST_CANCER_PROGENITORS_DN

For the Human gene set with the same name, see ZHANG_BREAST_CANCER_PROGENITORS_DN

Standard name ZHANG_BREAST_CANCER_PROGENITORS_DN
Systematic name MM760
Brief description Genes down-regulated in cancer stem cells isolated from mammary tumors compared to the non-tumorigenic cells.
Full description or abstract Using a syngeneic p53-null mouse mammary gland tumor model that closely mimics human breast cancer, we have identified, by limiting dilution transplantation and in vitro mammosphere assay, a Lin(-)CD29(H)CD24(H) subpopulation of tumor-initiating cells. Upon subsequent transplantation, this subpopulation generated heterogeneous tumors that displayed properties similar to the primary tumor. Analysis of biomarkers suggests the Lin(-)CD29(H)CD24(H) subpopulation may have arisen from a bipotent mammary progenitor. Differentially expressed genes in the Lin(-)CD29(H)CD24(H) mouse mammary gland tumor-initiating cell population include those involved in DNA damage response and repair, as well as genes involved in epigenetic regulation previously shown to be critical for stem cell self-renewal. These studies provide in vitro and in vivo data that support the cancer stem cell (CSC) hypothesis. Furthermore, this p53-null mouse mammary tumor model may allow us to identify new CSC markers and to test the functional importance of these markers.
Collection M2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 18559513   Authors: Zhang M,Behbod F,Atkinson RL,Landis MD,Kittrell F,Edwards D,Medina D,Tsimelzon A,Hilsenbeck S,Green JE,Michalowska AM,Rosen JM
Exact source Table 5S: fold < 0.5
Related gene sets (show 1 additional gene sets from the source publication)

(show 8 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Mus musculus
Contributed by Leona Saunders (MSigDB Team)
Source platform or
identifier namespace
AFFY_Mouse430
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
Mouse Transcriptomic BodyMap compendium

Legacy heatmaps (PNG)
Mouse Transcriptomic BodyMap compendium
Advanced query Further investigate these 144 genes
Show members (show 169 source identifiers mapped to 144 genes)
Version history 2022.1.Mm: First Introduced.

See MSigDB license terms here. Please note that certain gene sets have special access terms.