Mouse Gene Set: ZENG_GU_ICB_CONTROL_METAGENE_21_PRECICTIVE_ICB_RESISTANCE


Standard name ZENG_GU_ICB_CONTROL_METAGENE_21_PRECICTIVE_ICB_RESISTANCE
Systematic name MM17087
Brief description Metagene derived from the control samples, found to be predictive of immune checkpoint blockade treatment resistance, not otherwise discussed.
Full description or abstract Most patients with cancer are refractory to immune checkpoint blockade (ICB) therapy, and proper patient stratification remains an open question. Primary patient data suffer from high heterogeneity, low accessibility, and lack of proper controls. In contrast, syngeneic mouse tumor models enable controlled experiments with ICB treatments. Using transcriptomic and experimental variables from >700 ICB-treated/control syngeneic mouse tumors, [this study] developed a machine learning framework to model tumor immunity and identify factors influencing ICB response. Projected on human immunotherapy trial data, [this study] found that the model can predict clinical ICB response. [This study] further applied the model to predicting ICB-responsive/resistant cancer types in The Cancer Genome Atlas, which agreed well with existing clinical reports.
Collection M2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 36240281   Authors: Zeng Z,Gu SS,Wong CJ,Yang L,Ouardaoui N,Li D,Zhang W,Brown M,Liu XS
Exact source Table S5. Top genes in different metagenes (control samples): metageneor21
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Source species Mus musculus
Contributed by Anthony Castanza (MSigDB Team)
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identifier namespace		 MOUSE_GENE_SYMBOL
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