Mouse Gene Set: XIE_TRASTUZUMAB_CARDIOTOXICITY_LNCRNA_GENES


Standard name XIE_TRASTUZUMAB_CARDIOTOXICITY_LNCRNA_GENES
Systematic name MM17489
Brief description Ensembl mapped genes derived from the 270 lncRNAs that were found to be significantly dysregulated in the trastuzumab-induced cardiotoxicity (TIC) model
Full description or abstract Abstract: Trastuzumab-induced cardiotoxicity (TIC) is a common and serious disease with abnormal cardiac function. Accumulating evidence has indicated certain non-coding RNAs (ncRNAs), functioning as competing endogenous RNAs (ceRNAs), impacting the progression of cardiovascular diseases. Nonetheless, the specific involvement of ncRNA-mediated ceRNA regulatory mechanisms in TIC remains elusive. The present research aims to comprehensively investigate changes in the expressions of all ncRNA using whole-transcriptome RNA sequencing. The sequencing analysis unveiled significant dysregulation, identifying a total of 43 circular RNAs (circRNAs), 270 long noncoding RNAs (lncRNAs), 12 microRNAs (miRNAs), and 4131 mRNAs in trastuzumab-treated mouse hearts. Subsequently, circRNA-based ceRNA networks consisting of 82 nodes and 91 edges, as well as lncRNA-based ceRNA networks comprising 111 nodes and 112 edges, were constructed. Using the CytoNCA plugin, pivotal genes - miR-31-5p and miR-644-5p - were identified within these networks, exhibiting potential relevance in TIC treatment. Additionally, KEGG and GO analyses were conducted to explore the functional pathways associated with the genes within the ceRNA networks. The outcomes of the predicted ceRNAs and bioinformatics analyses elucidated the plausible involvement of ncRNAs in TIC pathogenesis. This insight contributes to a better understanding of underlying mechanisms and aids in identifying promising targets for effective prevention and treatment strategies.
Collection M2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 38577019   Authors: Xie S,Zhou N,Su N,Xiao Z,Wei S,Yang Y,Liu J,Li W,Zhang B
Exact source Supplementary Table S2. Differentially expressed lncRNAs, Ensembl Transcript IDs mapped to Ensembl Gene IDs
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External links https://www.sciencedirect.com/science/article/pii/S2468054024000258
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Source species Mus musculus
Contributed by Anthony Castanza (MSigDB Team)
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identifier namespace		 Mouse_Ensembl_Gene_ID
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Version history 2024.1.Mm: First Introduced.

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