Mouse Gene Set: WANG_LSD1_TARGETS_DN

For the Human gene set with the same name, see WANG_LSD1_TARGETS_DN

Standard name WANG_LSD1_TARGETS_DN
Systematic name MM740
Brief description Genes down-regulated after Cre-lox knockout of LSD1 [GeneID=23028] in pituitary.
Full description or abstract Precise control of transcriptional programmes underlying metazoan development is modulated by enzymatically active co-regulatory complexes, coupled with epigenetic strategies. One thing that remains unclear is how specific members of histone modification enzyme families, such as histone methyltransferases and demethylases, are used in vivo to simultaneously orchestrate distinct developmental gene activation and repression programmes. Here, we report that the histone lysine demethylase, LSD1--a component of the CoREST-CtBP co-repressor complex--is required for late cell-lineage determination and differentiation during pituitary organogenesis. LSD1 seems to act primarily on target gene activation programmes, as well as in gene repression programmes, on the basis of recruitment of distinct LSD1-containing co-activator or co-repressor complexes. LSD1-dependent gene repression programmes can be extended late in development with the induced expression of ZEB1, a Krüppel-like repressor that can act as a molecular beacon for recruitment of the LSD1-containing CoREST-CtBP co-repressor complex, causing repression of an additional cohort of genes, such as Gh, which previously required LSD1 for activation. These findings suggest that temporal patterns of expression of specific components of LSD1 complexes modulate gene regulatory programmes in many mammalian organs.
Collection M2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 17392792   Authors: Wang J,Scully K,Zhu X,Cai L,Zhang J,Prefontaine GG,Krones A,Ohgi KA,Zhu P,Garcia-Bassets I,Liu F,Taylor H,Lozach J,Jayes FL,Korach KS,Glass CK,Fu XD,Rosenfeld MG
Exact source Fig 4AS
Related gene sets (show 1 additional gene sets from the source publication)

(show 30 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Mus musculus
Contributed by Jessica Robertson (MSigDB Team)
Source platform or
identifier namespace		 MOUSE_GENE_SYMBOL
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
Mouse Transcriptomic BodyMap compendium

Legacy heatmaps (PNG)
Mouse Transcriptomic BodyMap compendium
Advanced query Further investigate these 37 genes
Show members (show 40 source identifiers mapped to 37 genes)
Version history 2022.1.Mm: First Introduced.

See MSigDB license terms here. Please note that certain gene sets have special access terms.