Mouse Gene Set: SCHRAETS_MLL_TARGETS_DN

For the Human gene set with the same name, see SCHRAETS_MLL_TARGETS_DN

Standard name SCHRAETS_MLL_TARGETS_DN
Systematic name MM1258
Brief description Genes down-regulated in fibroblasts from MLL [GeneID=4297] knockout mice.
Full description or abstract The human mixed lineage leukemia (MLL) gene is involved in about 50 different chromosomal translocations, associated with the disease phenotype of acute leukemia. However, the normal function of MLL is less understood. Homozygous knockouts of murine Mll were embryonal lethal, while heterozygous disruption led to aberrant hox gene expression associated with skeletal malformations, growth retardation, and impaired hematopoiesis. To understand MLL functions on the molecular level, gene expression profiling experiments were performed with a pair of murine cell lines (MLL(+/+) and MLL(-/-)). Microarray hybridization experiments revealed 197 potential target genes that are differentially expressed, providing new and important clues about MLL functions.
Collection M2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 12789274   Authors: Schraets D,Lehmann T,Dingermann T,Marschalek R
Exact source Table 2
Related gene sets (show 1 additional gene sets from the source publication)

(show 14 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Mus musculus
Contributed by Arthur Liberzon (MSigDB Team)
Source platform or
identifier namespace		 MOUSE_SEQ_ACCESSION
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
Mouse Transcriptomic BodyMap compendium

Legacy heatmaps (PNG)
Mouse Transcriptomic BodyMap compendium
Advanced query Further investigate these 35 genes
Show members (show 40 source identifiers mapped to 35 genes)
Version history 2022.1.Mm: First Introduced.

See MSigDB license terms here. Please note that certain gene sets have special access terms.