Mouse Gene Set: NABA_MATRISOME_PRIMARY_METASTATIC_LUNG_TUMOR


Standard name NABA_MATRISOME_PRIMARY_METASTATIC_LUNG_TUMOR
Systematic name MM17054
Brief description Matrisome proteins detected in significantly different abundance in primary lung tumor as compared to normal lung.
Full description or abstract In this study, we investigated the role of the extracellular matrix (ECM) in the underlying biology of lung adenocarcinoma using an autochthonous mouse model that recapitulates the complexity of cancer initiation and progression to characterize the ECM composition of normal lung, fibrotic lung, lung tumors, and metastases. We isolated normal, healthy lung tissues from wild-type (WT) mice and microdissected KrasG12D/p53-/- primary lung tumors (KP tumors) and associated metastases to the mediastinal lymph node. Quantitative mass spectrometric profiling of the ECM composition of normal lung, fibrotic lung (from bleomycin-treated mice), primary lung tumors, and lung metastases to the lymph nodes uncovered specific signatures distinguishing these tissues. This gene set lists the matrisome proteins detected in significantly different abundance in primary lung tumor as compared to normal lung.
Collection M2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 28652369   Authors: Gocheva V,Naba A,Bhutkar A,Guardia T,Miller KM,Li CM,Dayton TL,Sanchez-Rivera FJ,Kim-Kiselak C,Jailkhani N,Winslow MM,Del Rosario A,Hynes RO,Jacks T
Exact source Dataset S3, Figure 3D. ECM signatures distinguish fibrotic, primary tumor, and metastatic states.
Related gene sets (show 2 additional gene sets from the source publication)

(show 14 gene sets from the same authors)
External links https://doi.org/10.1073/pnas.1707054114
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Source species Mus musculus
Contributed by Alexandra Naba (University of Illinois Chicago)
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identifier namespace		 MOUSE_GENE_SYMBOL
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Version history 2023.2.Mm: First Introduced.

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