Mouse Gene Set: NABA_MATRISOME_HYPERPLASTIC_PANCREATIC_ISLETS


Standard name NABA_MATRISOME_HYPERPLASTIC_PANCREATIC_ISLETS
Systematic name MM17051
Brief description Matrisome proteins detected in significantly higher abundance during the hyperplastic stage of insulinoma progression compared to normal islets and relative to insulinomas (RIP-Tag2 model).
Full description or abstract In this study, we aimed to characterize changes in the extracellular matrix (ECM) composition during insulinoma progression using a quantitative proteomics approach. To do so, we chose a mouse model of insulinoma, a subtype of pancreatic neuroendocrine tumors, characterized by the expression of SV40 large T antigen (Tag) in pancreatic beta-cells driven by the rat insulin promoter (RIP) (RIP1-Tag2 model). This model follows a well-defined timeline of tumor progression: hyperplastic islets appear by 4 weeks of age, angiogenic islets by 7-9 weeks, solid tumors at 10 weeks, and large and invasive adenomas by 12-13 weeks. Using quantitative proteomics based on isobaric peptide labeling (iTRAQ), we profiled the ECM proteomes or matrisomes of various stages: normal pancreatic islets, hyperplastic islets, angiogenic pancreatic islets, and insulinomas. We focused on ECM and ECM-associated proteins along with proteins found in only one of the two replicates but with at least two unique peptides. Applying a moderated F-test, we identified proteins detected in statistically significantly different abundance in tumor samples (hyperplastic, angiogenic islets or isulinomas) as compared to normal pancreatic islets. The gene set lists the matrisome proteins detected in significantly higher abundance during the hyperplastic stage of insulinoma progression as compared to normal islets and later stage insulinomas.
Collection M2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 28071719   Authors: Naba A,Clauser KR,Mani DR,Carr SA,Hynes RO
Exact source Supplementary Table 1: srep40495-s2.xls, Figure 3B-G: 35 ECM and ECM-associated proteins detected in significantly different abundance during insulinoma progression.
Related gene sets (show 2 additional gene sets from the source publication)

(show 12 gene sets from the same authors)
External links https://doi.org/10.1038/srep40495
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Source species Mus musculus
Contributed by Alexandra Naba (University of Illinois Chicago)
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identifier namespace		 MOUSE_GENE_SYMBOL
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Version history 2023.2.Mm: First Introduced.

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