Mouse Gene Set: MATZUK_MALE_REPRODUCTION_SERTOLI

For the Human gene set with the same name, see MATZUK_MALE_REPRODUCTION_SERTOLI

Standard name MATZUK_MALE_REPRODUCTION_SERTOLI
Systematic name MM764
Brief description Genes important for Sertoli, peritubular, Leydig and interstitial cells, based on mouse models with male reproductive defects.
Full description or abstract Reproduction is required for the survival of all mammalian species, and thousands of essential 'sex' genes are conserved through evolution. Basic research helps to define these genes and the mechanisms responsible for the development, function and regulation of the male and female reproductive systems. However, many infertile couples continue to be labeled with the diagnosis of idiopathic infertility or given descriptive diagnoses that do not provide a cause for their defect. For other individuals with a known etiology, effective cures are lacking, although their infertility is often bypassed with assisted reproductive technologies (ART), some accompanied by safety or ethical concerns. Certainly, progress in the field of reproduction has been realized in the twenty-first century with advances in the understanding of the regulation of fertility, with the production of over 400 mutant mouse models with a reproductive phenotype and with the promise of regenerative gonadal stem cells. Indeed, the past six years have witnessed a virtual explosion in the identification of gene mutations or polymorphisms that cause or are linked to human infertility. Translation of these findings to the clinic remains slow, however, as do new methods to diagnose and treat infertile couples. Additionally, new approaches to contraception remain elusive. Nevertheless, the basic and clinical advances in the understanding of the molecular controls of reproduction are impressive and will ultimately improve patient care.
Collection M2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 18989307   Authors: Matzuk MM,Lamb DJ
Exact source Fig. 5: Sertoli, peritubular, Leydig and/or interstitial cells
Related gene sets (show 4 additional gene sets from the source publication)

(show 2 gene sets from the same authors)
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Source species Mus musculus
Contributed by Jessica Robertson (MSigDB Team)
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identifier namespace		 MOUSE_GENE_SYMBOL
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Version history 2022.1.Mm: First Introduced.

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