Mouse Gene Set: LIN_NPAS4_TARGETS_UP

For the Human gene set with the same name, see LIN_NPAS4_TARGETS_UP

Standard name LIN_NPAS4_TARGETS_UP
Systematic name MM767
Brief description Genes up-regulated in neurons after NPAS4 [GeneID=266743] knockdown by RNAi.
Full description or abstract Neuronal activity regulates the development and maturation of excitatory and inhibitory synapses in the mammalian brain. Several recent studies have identified signalling networks within neurons that control excitatory synapse development. However, less is known about the molecular mechanisms that regulate the activity-dependent development of GABA (gamma-aminobutyric acid)-releasing inhibitory synapses. Here we report the identification of a transcription factor, Npas4, that plays a role in the development of inhibitory synapses by regulating the expression of activity-dependent genes, which in turn control the number of GABA-releasing synapses that form on excitatory neurons. These findings demonstrate that the activity-dependent gene program regulates inhibitory synapse development, and suggest a new role for this program in controlling the homeostatic balance between synaptic excitation and inhibition.
Collection M2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 18815592   Authors: Lin Y,Bloodgood BL,Hauser JL,Lapan AD,Koon AC,Kim TK,Hu LS,Malik AN,Greenberg ME
Exact source Table 1S: U = Up-regulated
Related gene sets (show 1 additional gene sets from the source publication)

(show 19 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Mus musculus
Contributed by Jessica Robertson (MSigDB Team)
Source platform or
identifier namespace
AFFY_Mouse430
Dataset references (show 3 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
Mouse Transcriptomic BodyMap compendium

Legacy heatmaps (PNG)
Mouse Transcriptomic BodyMap compendium
Advanced query Further investigate these 175 genes
Show members (show 238 source identifiers mapped to 175 genes)
Version history 2022.1.Mm: First Introduced.

See MSigDB license terms here. Please note that certain gene sets have special access terms.