Mouse Gene Set: KAMMINGA_EZH2_TARGETS

For the Human gene set with the same name, see KAMMINGA_EZH2_TARGETS

Standard name KAMMINGA_EZH2_TARGETS
Systematic name MM1159
Brief description Putative targets or partners of EZH2 [GeneID=2146] in hematopoietic stem cells.
Full description or abstract The molecular mechanism responsible for a decline of stem cell functioning after replicative stress remains unknown. We used mouse embryonic fibroblasts (MEFs) and hematopoietic stem cells (HSCs) to identify genes involved in the process of cellular aging. In proliferating and senescent MEFs one of the most differentially expressed transcripts was Enhancer of zeste homolog 2 (Ezh2), a Polycomb group protein (PcG) involved in histone methylation and deacetylation. Retroviral overexpression of Ezh2 in MEFs resulted in bypassing of the senescence program. More importantly, whereas normal HSCs were rapidly exhausted after serial transplantations, overexpression of Ezh2 completely conserved long-term repopulating potential. Animals that were reconstituted with 3 times serially transplanted control bone marrow cells all died due to hematopoietic failure. In contrast, similarly transplanted Ezh2-overexpressing stem cells restored stem cell quality to normal levels. In a genetic genomics screen, we identified novel putative Ezh2 target or partner stem cell genes that are associated with chromatin modification. Our data suggest that stabilization of the chromatin structure preserves HSC potential after replicative stress.
Collection M2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 16293602   Authors: Kamminga LM,Bystrykh LV,de Boer A,Houwer S,Douma J,Weersing E,Dontje B,de Haan G
Exact source Table 1
Related gene sets (show 1 additional gene sets from the source publication)

(show 10 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Mus musculus
Contributed by Kevin Vogelsang (MSigDB Team)
Source platform or
identifier namespace		 MOUSE_GENE_SYMBOL
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
Mouse Transcriptomic BodyMap compendium

Legacy heatmaps (PNG)
Mouse Transcriptomic BodyMap compendium
Advanced query Further investigate these 41 genes
Show members (show 41 source identifiers mapped to 41 genes)
Version history 2022.1.Mm: First Introduced.

See MSigDB license terms here. Please note that certain gene sets have special access terms.