Mouse Gene Set: HOLLERN_MICROACINAR_BREAST_TUMOR_UP

For the Human gene set with the same name, see HOLLERN_MICROACINAR_BREAST_TUMOR_UP

Standard name HOLLERN_MICROACINAR_BREAST_TUMOR_UP
Systematic name MM968
Brief description Genes that have high expression in mammary tumors of microacinar histology.
Full description or abstract Human breast cancer has been characterized by extensive transcriptional heterogeneity, with dominant patterns reflected in the intrinsic subtypes. Mouse models of breast cancer also have heterogeneous transcriptomes and we noted that specific histological subtypes were associated with particular subsets. We hypothesized that unique sets of genes define each tumor histological type across mouse models of breast cancer. Using mouse models that contained both gene expression data and expert pathologist classification of tumor histology on a sample by sample basis, we predicted and validated gene expression signatures for Papillary, EMT, Microacinar and other histological subtypes. These signatures predict known histological events across murine breast cancer models and identify counterparts of mouse mammary tumor types in subtypes of human breast cancer. Importantly, the EMT, Adenomyoepithelial, and Solid signatures were predictive of clinical events in human breast cancer. In addition, a pan-cancer comparison revealed that the histological signatures were active in a variety of human cancers such as lung, oral, and esophageal squamous tumors. Finally, the differentiation status and transcriptional activity implicit within these signatures was identified. These data reveal that within tumor histology groups are unique gene expression profiles of differentiation and pathway activity that stretch well beyond the transgenic initiating events and that have clear applicability to human cancers. As a result, our work provides a predictive resource and insights into possible mechanisms that govern tumor heterogeneity.
Collection M2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 29346386   Authors: Hollern DP,Swiatnicki MR,Andrechek ER
Exact source File S1: Upregulated_In_Microacinar
Related gene sets (show 5 additional gene sets from the source publication)
External links
Filtered by similarity ?
Source species Mus musculus
Contributed by Daniel Hollern (University of North Carolina)
Source platform or
identifier namespace		 AFFY_Mouse430
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
Mouse Transcriptomic BodyMap compendium

Legacy heatmaps (PNG)
Mouse Transcriptomic BodyMap compendium
Advanced query Further investigate these 48 genes
Show members (show 66 source identifiers mapped to 48 genes)
Version history 2022.1.Mm: First Introduced.

See MSigDB license terms here. Please note that certain gene sets have special access terms.