Catalysis of the reaction: NAD+ + H2O = ADP-D-ribose + nicotinamide + H+, in a two step reaction: first an ADP-ribosyl cyclase reaction to synthesise cyclic ADP-ribose, followed by a cyclic ADP-ribose hydrolase reaction to generate (linear) ADP-ribose. [EC:3.2.2.6, PMID:11866528]
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M5: Ontology GO: Gene Ontology GO:MF: GO Molecular Function
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