Mouse Gene Set: CHEN_LIVER_METABOLISM_QTL_CIS

For the Human gene set with the same name, see CHEN_LIVER_METABOLISM_QTL_CIS

Standard name CHEN_LIVER_METABOLISM_QTL_CIS
Systematic name MM827
Brief description Cis-regulated expression quantitative loci (cis-eQTL) in the liver that contribute to metabolic quantitative traits (weight, fat mass, and plasma glucose and cholesterol levels).
Full description or abstract Identifying variations in DNA that increase susceptibility to disease is one of the primary aims of genetic studies using a forward genetics approach. However, identification of disease-susceptibility genes by means of such studies provides limited functional information on how genes lead to disease. In fact, in most cases there is an absence of functional information altogether, preventing a definitive identification of the susceptibility gene or genes. Here we develop an alternative to the classic forward genetics approach for dissecting complex disease traits where, instead of identifying susceptibility genes directly affected by variations in DNA, we identify gene networks that are perturbed by susceptibility loci and that in turn lead to disease. Application of this method to liver and adipose gene expression data generated from a segregating mouse population results in the identification of a macrophage-enriched network supported as having a causal relationship with disease traits associated with metabolic syndrome. Three genes in this network, lipoprotein lipase (Lpl), lactamase beta (Lactb) and protein phosphatase 1-like (Ppm1l), are validated as previously unknown obesity genes, strengthening the association between this network and metabolic disease traits. Our analysis provides direct experimental support that complex traits such as obesity are emergent properties of molecular networks that are modulated by complex genetic loci and environmental factors.
Collection M2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 18344982   Authors: Chen Y,Zhu J,Lum PY,Yang X,Pinto S,MacNeil DJ,Zhang C,Lamb J,Edwards S,Sieberts SK,Leonardson A,Castellini LW,Wang S,Champy MF,Zhang B,Emilsson V,Doss S,Ghazalpour A,Horvath S,Drake TA,Lusis AJ,Schadt EE
Exact source Table 1S
Related gene sets (show 1 additional gene sets from the source publication)

(show 1803 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Mus musculus
Contributed by Arthur Liberzon (MSigDB Team)
Source platform or
identifier namespace		 MOUSE_GENE_SYMBOL
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
Mouse Transcriptomic BodyMap compendium

Legacy heatmaps (PNG)
Mouse Transcriptomic BodyMap compendium
Advanced query Further investigate these 99 genes
Show members (show 107 source identifiers mapped to 99 genes)
Version history 2022.1.Mm: First Introduced.

See MSigDB license terms here. Please note that certain gene sets have special access terms.