Mouse Gene Set: BIOCARTA_VIP_PATHWAY

For the Human gene set with the same name, see BIOCARTA_VIP_PATHWAY

Standard name BIOCARTA_VIP_PATHWAY
Systematic name MM1441
Brief description Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells
Full description or abstract Vasoactive intestinal peptide (VIP) and the structurally related pituitary adenylate cyclase-activating polypeptide (PACAP), two neuropeptides present in the lymphoid microenvironment, elicit a broad spectrum of biological functions, including the modulation of innate and adaptive immunity. Another important immunoregulatory function of VIP and PACAP is their inhibition effect on AICD in T cells. They inhibit the TCR-stimulated FasL expression and apoptosis of T cell through specific receptors and induction of intracellular cAMP. VIP down-regulate c-Myc synthesis, the NF-AT-dependent Egr2 and Egr3 expression, the NF-AT and NF-kB.
Collection M2: Curated
      CP: Canonical Pathways
            CP:BIOCARTA: BioCarta Pathways
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External links https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/mouse/m_vipPathway.gif
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Source species Mus musculus
Contributed by BioCarta
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identifier namespace		 MOUSE_SEQ_ACCESSION
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Version history 2022.1.Mm: First Introduced.

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