Mouse Gene Set: BIOCARTA_GPCR_PATHWAY

For the Human gene set with the same name, see BIOCARTA_GPCR_PATHWAY

Standard name BIOCARTA_GPCR_PATHWAY
Systematic name MM1495
Brief description Signaling Pathway from G-Protein Families
Full description or abstract G-aS-coupled receptors stimulate adenylyl cyclase (AC), which synthesizes cAMP from ATP. In contrast Gai-coupled receptors inhibit AC and so reduce cAMP formation. The bg subunits from Gai and other G proteins are able to activate the MAP kinase pathways and PLCb. GPCRs coupled to the Gaq family of G proteins stimulate PLCb, which cleaves membrane phospholipids to produce IP3, which mobilizes intracellular calcium, and DAG, which activates PKC. Second messenger pathways then activate a range of effector systems to change cell behaviour; in many cases this includes the regulation of gene transcription. Dotted line shows a more indirect pathway.
Collection M2: Curated
      CP: Canonical Pathways
            CP:BIOCARTA: BioCarta Pathways
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External links https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/mouse/m_gpcrPathway.gif
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Source species Mus musculus
Contributed by BioCarta
Source platform or
identifier namespace		 MOUSE_SEQ_ACCESSION
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Version history 2022.1.Mm: First Introduced.

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