Human Gene Set: ZHANG_TLX_TARGETS_60HR_UP

Standard name

ZHANG_TLX_TARGETS_60HR_UP

Systematic name

M1914

Brief description

Genes up-regulated in neural stem cells (NSC) at 60 h after cre-lox knockout of TLX (NR2E1) [GeneID=7101].

Full description or abstract

Neurogenesis persists in the adult brain and can be regulated by a plethora of external stimuli, such as learning, memory, exercise, environment and stress. Although newly generated neurons are able to migrate and preferentially incorporate into the neural network, how these cells are molecularly regulated and whether they are required for any normal brain function are unresolved questions. The adult neural stem cell pool is composed of orphan nuclear receptor TLX-positive cells. Here, using genetic approaches in mice, we demonstrate that TLX (also called NR2E1) regulates adult neural stem cell proliferation in a cell-autonomous manner by controlling a defined genetic network implicated in cell proliferation and growth. Consequently, specific removal of TLX from the adult mouse brain through inducible recombination results in a significant reduction of stem cell proliferation and a marked decrement in spatial learning. In contrast, the resulting suppression of adult neurogenesis does not affect contextual fear conditioning, locomotion or diurnal rhythmic activities, indicating a more selective contribution of newly generated neurons to specific cognitive functions.

Collection

ARCHIVED: Archived Founder gene sets that are referenced by current Hallmarks
C2_NONE: ARCHIVED Curated
C2_CGP: ARCHIVED Chemical and Genetic Perturbations

Source publication

Pubmed 18235445 Authors: Zhang CL,Zou Y,He W,Gage FH,Evans RM

Exact source

Table 2S: up-regulated

Related gene sets

(show 5 additional gene sets from the source publication)

(show 100 gene sets from the same authors)

External links

Filtered by similarity ?

Source species

Mus musculus

Contributed by

Jessica Robertson (MSigDB Team)

Source platform or
identifier namespace

UniGene_ID

Dataset references

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format: grp | gmt | xml | json | TSV metadata

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Compendia expression profiles ?

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(show 307 source identifiers mapped to 0 genes)

Source Id	NCBI (Entrez) Gene Id	Gene Symbol	Gene Description
Mm.1
Mm.100940
Mm.102141
Mm.10299
Mm.110220
Mm.117429
Mm.1175
Mm.119
Mm.1193
Mm.121361
Mm.12746
Mm.128153
Mm.131074
Mm.1360
Mm.136586
Mm.13787
Mm.143716
Mm.143742
Mm.14638
Mm.149029
Mm.1528
Mm.153061
Mm.153272
Mm.153891
Mm.154564
Mm.154906
Mm.155696
Mm.156771
Mm.1568
Mm.157545
Mm.157904
Mm.158251
Mm.159028
Mm.159453
Mm.1682
Mm.171186
Mm.17185
Mm.172346
Mm.173068
Mm.178
Mm.182396
Mm.182912
Mm.1860
Mm.186361
Mm.1894
Mm.193539
Mm.195663
Mm.196239
Mm.196295
Mm.197534
Mm.19825
Mm.19904
Mm.200608
Mm.200792
Mm.20437
Mm.20488
Mm.206505
Mm.207996
Mm.209041
Mm.20944
Mm.20948
Mm.209813
Mm.2103
Mm.210815
Mm.21109
Mm.212395
Mm.212549
Mm.212812
Mm.212927
Mm.214328
Mm.21440
Mm.21697
Mm.218286
Mm.218590
Mm.218639
Mm.21976
Mm.219813
Mm.220224
Mm.220289
Mm.2213
Mm.2214
Mm.222685
Mm.22670
Mm.22699
Mm.227202
Mm.229330
Mm.231091
Mm.231395
Mm.23156
Mm.23230
Mm.233470
Mm.233951
Mm.234441
Mm.235007
Mm.235998
Mm.23608
Mm.236401
Mm.2381
Mm.23932
Mm.239470
Mm.239605
Mm.23963
Mm.24001
Mm.2407
Mm.241282
Mm.24308
Mm.245154
Mm.246513
Mm.24670
Mm.246881
Mm.247352
Mm.247564
Mm.247951
Mm.248049
Mm.249386
Mm.250438
Mm.251322
Mm.252
Mm.253564
Mm.25775
Mm.258094
Mm.25848
Mm.259260
Mm.259315
Mm.259673
Mm.260137
Mm.261676
Mm.265264
Mm.265512
Mm.26553
Mm.265917
Mm.265990
Mm.2675
Mm.26787
Mm.268710
Mm.268798
Mm.270484
Mm.27114
Mm.271668
Mm.271854
Mm.271877
Mm.272183
Mm.272321
Mm.272770
Mm.273659
Mm.273662
Mm.273874
Mm.273905
Mm.275003
Mm.275036
Mm.275845
Mm.276155
Mm.276408
Mm.277533
Mm.27757
Mm.27769
Mm.277719
Mm.27806
Mm.27816
Mm.279256
Mm.27968
Mm.280038
Mm.280230
Mm.280459
Mm.280536
Mm.281298
Mm.281452
Mm.28212
Mm.283495
Mm.28357
Mm.28376
Mm.28623
Mm.287014
Mm.28708
Mm.287359
Mm.28771
Mm.288474
Mm.288642
Mm.289706
Mm.290126
Mm.290341
Mm.290442
Mm.290534
Mm.290802
Mm.290950
Mm.291442
Mm.29189
Mm.292042
Mm.292050
Mm.292168
Mm.292276
Mm.293255
Mm.293605
Mm.294007
Mm.295284
Mm.295306
Mm.29561
Mm.29647
Mm.29660
Mm.29768
Mm.297964
Mm.29846
Mm.301204
Mm.301626
Mm.301646
Mm.305152
Mm.305725
Mm.3092
Mm.32020
Mm.3272
Mm.32744
Mm.32780
Mm.328872
Mm.3303
Mm.331089
Mm.331626
Mm.332293
Mm.332295
Mm.332931
Mm.333798
Mm.334841
Mm.335454
Mm.335752
Mm.336625
Mm.336848
Mm.338613
Mm.339792
Mm.34046
Mm.34109
Mm.34113
Mm.341776
Mm.34330
Mm.34346
Mm.34497
Mm.3459
Mm.34650
Mm.347362
Mm.348266
Mm.352763
Mm.35444
Mm.35705
Mm.35817
Mm.358583
Mm.358724
Mm.358797
Mm.358954
Mm.359030
Mm.36745
Mm.371656
Mm.373539
Mm.377880
Mm.378928
Mm.379009
Mm.379071
Mm.379089
Mm.379360
Mm.379387
Mm.37950
Mm.383168
Mm.384029
Mm.38608
Mm.386754
Mm.38801
Mm.3925
Mm.3959
Mm.39725
Mm.3992
Mm.41261
Mm.41329
Mm.4263
Mm.4325
Mm.43278
Mm.4337
Mm.4361
Mm.4454
Mm.46019
Mm.4628
Mm.4657
Mm.4881
Mm.4909
Mm.5002
Mm.50109
Mm.5053
Mm.5121
Mm.5145
Mm.5236
Mm.5244
Mm.5510
Mm.5675
Mm.6095
Mm.6424
Mm.6483
Mm.6523
Mm.6743
Mm.6826
Mm.7838
Mm.795
Mm.856
Mm.87246
Mm.87663
Mm.89926
Mm.9075
Mm.930
Mm.94371
Mm.945
Mm.9745
Mm.98200

Version history

3.1: First introduced

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