Human Gene Set: ZHANG_TLX_TARGETS_60HR_DN

Standard name

ZHANG_TLX_TARGETS_60HR_DN

Systematic name

M1915

Brief description

Genes down-regulated in neural stem cells (NSC) at 60 h after cre-lox knockout of TLX (NR2E1) [GeneID=7101].

Full description or abstract

Neurogenesis persists in the adult brain and can be regulated by a plethora of external stimuli, such as learning, memory, exercise, environment and stress. Although newly generated neurons are able to migrate and preferentially incorporate into the neural network, how these cells are molecularly regulated and whether they are required for any normal brain function are unresolved questions. The adult neural stem cell pool is composed of orphan nuclear receptor TLX-positive cells. Here, using genetic approaches in mice, we demonstrate that TLX (also called NR2E1) regulates adult neural stem cell proliferation in a cell-autonomous manner by controlling a defined genetic network implicated in cell proliferation and growth. Consequently, specific removal of TLX from the adult mouse brain through inducible recombination results in a significant reduction of stem cell proliferation and a marked decrement in spatial learning. In contrast, the resulting suppression of adult neurogenesis does not affect contextual fear conditioning, locomotion or diurnal rhythmic activities, indicating a more selective contribution of newly generated neurons to specific cognitive functions.

Collection

ARCHIVED: Archived Founder gene sets that are referenced by current Hallmarks
C2_NONE: ARCHIVED Curated
C2_CGP: ARCHIVED Chemical and Genetic Perturbations

Source publication

Pubmed 18235445 Authors: Zhang CL,Zou Y,He W,Gage FH,Evans RM

Exact source

Table 2S: down-regulated

Related gene sets

(show 5 additional gene sets from the source publication)

(show 100 gene sets from the same authors)

External links

Filtered by similarity ?

Source species

Mus musculus

Contributed by

Jessica Robertson (MSigDB Team)

Source platform or
identifier namespace

UniGene_ID

Dataset references

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format: grp | gmt | xml | json | TSV metadata

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Compendia expression profiles ?

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(show 289 source identifiers mapped to 0 genes)

Source Id	NCBI (Entrez) Gene Id	Gene Symbol	Gene Description
Mm.10
Mm.102305
Mm.103812
Mm.11434
Mm.116721
Mm.116997
Mm.117581
Mm.120919
Mm.12239
Mm.1248
Mm.12553
Mm.12568
Mm.12829
Mm.128580
Mm.12932
Mm.131150
Mm.13145
Mm.136217
Mm.1393
Mm.148877
Mm.149071
Mm.1500
Mm.150972
Mm.151315
Mm.153202
Mm.154275
Mm.154378
Mm.154511
Mm.159684
Mm.16110
Mm.161119
Mm.163339
Mm.1643
Mm.16525
Mm.16549
Mm.165735
Mm.16711
Mm.16753
Mm.173953
Mm.178684
Mm.181661
Mm.18210
Mm.189102
Mm.1904
Mm.1923
Mm.194368
Mm.196219
Mm.196220
Mm.197486
Mm.202337
Mm.204634
Mm.206841
Mm.207534
Mm.207767
Mm.20912
Mm.209931
Mm.210745
Mm.21492
Mm.21516
Mm.215335
Mm.2185
Mm.218657
Mm.21873
Mm.22279
Mm.224233
Mm.22453
Mm.22506
Mm.22592
Mm.229110
Mm.229128
Mm.231
Mm.23185
Mm.23526
Mm.23596
Mm.236114
Mm.236211
Mm.23695
Mm.23828
Mm.23894
Mm.239865
Mm.240566
Mm.24250
Mm.24337
Mm.2437
Mm.244671
Mm.244703
Mm.24491
Mm.244975
Mm.24532
Mm.245746
Mm.245800
Mm.246398
Mm.246688
Mm.246869
Mm.247651
Mm.248361
Mm.249146
Mm.251638
Mm.25264
Mm.253533
Mm.253721
Mm.254530
Mm.255848
Mm.2565
Mm.2567
Mm.257181
Mm.257482
Mm.257590
Mm.257762
Mm.258059
Mm.259893
Mm.260009
Mm.260256
Mm.260545
Mm.261004
Mm.261025
Mm.261453
Mm.261681
Mm.261739
Mm.262059
Mm.262151
Mm.264435
Mm.265615
Mm.2661
Mm.266312
Mm.268395
Mm.268668
Mm.269857
Mm.270676
Mm.271603
Mm.272472
Mm.27256
Mm.272826
Mm.273405
Mm.273502
Mm.274222
Mm.274847
Mm.274961
Mm.275095
Mm.276044
Mm.276087
Mm.276338
Mm.276405
Mm.27705
Mm.277705
Mm.277779
Mm.27789
Mm.27997
Mm.279998
Mm.280895
Mm.28099
Mm.281149
Mm.281498
Mm.282499
Mm.282751
Mm.283046
Mm.283406
Mm.28420
Mm.28478
Mm.28560
Mm.286488
Mm.286593
Mm.2870
Mm.287173
Mm.287178
Mm.288179
Mm.28847
Mm.2903
Mm.290407
Mm.290830
Mm.291029
Mm.29133
Mm.291607
Mm.292016
Mm.292470
Mm.294154
Mm.295168
Mm.2952
Mm.29600
Mm.296106
Mm.29680
Mm.29755
Mm.297862
Mm.2981
Mm.298892
Mm.29890
Mm.29898
Mm.299887
Mm.2999
Mm.300
Mm.30052
Mm.3022
Mm.30222
Mm.305237
Mm.306482
Mm.307103
Mm.307315
Mm.31051
Mm.311974
Mm.317041
Mm.31911
Mm.32012
Mm.321654
Mm.32506
Mm.328305
Mm.328698
Mm.33118
Mm.333417
Mm.335237
Mm.335275
Mm.33764
Mm.338175
Mm.3411
Mm.34261
Mm.3488
Mm.349493
Mm.35061
Mm.35470
Mm.354719
Mm.35584
Mm.35788
Mm.35801
Mm.358634
Mm.358717
Mm.358937
Mm.359408
Mm.359982
Mm.362296
Mm.3636
Mm.364956
Mm.3655
Mm.36746
Mm.36817
Mm.370666
Mm.371692
Mm.37376
Mm.37801
Mm.378965
Mm.378997
Mm.379024
Mm.379060
Mm.379065
Mm.379078
Mm.3794
Mm.386835
Mm.39095
Mm.3941
Mm.4078
Mm.41044
Mm.4105
Mm.4168
Mm.4189
Mm.42040
Mm.42045
Mm.42196
Mm.42201
Mm.42203
Mm.4237
Mm.4379
Mm.4502
Mm.4505
Mm.45111
Mm.45645
Mm.4594
Mm.46539
Mm.46662
Mm.46777
Mm.4933
Mm.5048
Mm.5088
Mm.5110
Mm.5324
Mm.57220
Mm.60590
Mm.6458
Mm.6536
Mm.681
Mm.6973
Mm.7362
Mm.74730
Mm.78861
Mm.7952
Mm.8552
Mm.87616
Mm.87773
Mm.9199
Mm.9563
Mm.99
Mm.9916

Version history

3.1: First introduced

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