Human Gene Set: ZHANG_BREAST_CANCER_PROGENITORS_DN

For the Mouse gene set with the same name, see ZHANG_BREAST_CANCER_PROGENITORS_DN

Standard name ZHANG_BREAST_CANCER_PROGENITORS_DN
Systematic name M6489
Brief description Genes down-regulated in cancer stem cells isolated from mammary tumors compared to the non-tumorigenic cells.
Full description or abstract Using a syngeneic p53-null mouse mammary gland tumor model that closely mimics human breast cancer, we have identified, by limiting dilution transplantation and in vitro mammosphere assay, a Lin(-)CD29(H)CD24(H) subpopulation of tumor-initiating cells. Upon subsequent transplantation, this subpopulation generated heterogeneous tumors that displayed properties similar to the primary tumor. Analysis of biomarkers suggests the Lin(-)CD29(H)CD24(H) subpopulation may have arisen from a bipotent mammary progenitor. Differentially expressed genes in the Lin(-)CD29(H)CD24(H) mouse mammary gland tumor-initiating cell population include those involved in DNA damage response and repair, as well as genes involved in epigenetic regulation previously shown to be critical for stem cell self-renewal. These studies provide in vitro and in vivo data that support the cancer stem cell (CSC) hypothesis. Furthermore, this p53-null mouse mammary tumor model may allow us to identify new CSC markers and to test the functional importance of these markers.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 18559513   Authors: Zhang M,Behbod F,Atkinson RL,Landis MD,Kittrell F,Edwards D,Medina D,Tsimelzon A,Hilsenbeck S,Green JE,Michalowska AM,Rosen JM
Exact source Table 5S: fold < 0.5
Related gene sets (show 1 additional gene sets from the source publication)

(show 22 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Mus musculus
Contributed by Leona Saunders (MSigDB Team)
Source platform or
identifier namespace		 AFFY_Mouse430
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 142 genes
Gene families ? Categorize these 142 genes by gene family
Show members (show 169 source identifiers mapped to 142 genes)
Version history 3.0: First introduced

See MSigDB license terms here. Please note that certain gene sets have special access terms.