Human Gene Set: YOSHIMURA_MAPK8_TARGETS_DN


Standard name YOSHIMURA_MAPK8_TARGETS_DN
Systematic name M1885
Brief description Genes down-regulated in vascular smooth muscle cells (VSMC) by MAPK8 (JNK1) [GeneID=5599].
Full description or abstract Abdominal aortic aneurysm (AAA) is a common disease among elderly people that, when surgical treatment is inapplicable, results in progressive expansion and rupture of the aorta with high mortality. Although nonsurgical treatment for AAA is much awaited, few options are available because its molecular pathogenesis remains elusive. Here, we identify JNK as a proximal signaling molecule in the pathogenesis of AAA. Human AAA tissue showed a high level of phosphorylated JNK. We show that JNK programs a gene expression pattern in different cell types that cooperatively enhances the degradation of the extracellular matrix while suppressing biosynthetic enzymes of the extracellular matrix. Selective inhibition of JNK in vivo not only prevented the development of AAA but also caused regression of established AAA in two mouse models. Thus, JNK promotes abnormal extracellular matrix metabolism in the tissue of AAA and may represent a therapeutic target.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 16311603   Authors: Yoshimura K,Aoki H,Ikeda Y,Fujii K,Akiyama N,Furutani A,Hoshii Y,Tanaka N,Ricci R,Ishihara T,Esato K,Hamano K,Matsuzaki M
Exact source Table 1S: J.I. < 0
Related gene sets (show 1 additional gene sets from the source publication)

(show 6 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Rattus norvegicus
Contributed by Jessica Robertson (MSigDB Team)
Source platform or
identifier namespace		 AFFY_RG_U34
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 379 genes
Gene families ? Categorize these 379 genes by gene family
Show members (show 495 source identifiers mapped to 379 genes)
Version history 3.1: First introduced

See MSigDB license terms here. Please note that certain gene sets have special access terms.