Human Gene Set: YAO_HOXA10_TARGETS_VIA_PROGESTERONE_DN

For the Mouse gene set with the same name, see YAO_HOXA10_TARGETS_VIA_PROGESTERONE_DN

Standard name YAO_HOXA10_TARGETS_VIA_PROGESTERONE_DN
Systematic name M4435
Brief description Genes down-regulated in the uteri of ovariectomized mice 6 h after progesterone [PubChem=5994] injection: HOXA10 [GeneID=3206] knockout vs wild type animals.
Full description or abstract Human infertility and recurrent pregnancy loss caused by implantation defects are poorly understood. Hoxa-10-deficient female mice have severe infertility and recurrent pregnancy loss due to defective uterine implantation. Gene expression profiling experiments reveal that Hoxa-10 is an important regulator of two critical events in implantation: stromal cell proliferation and local immunosuppression. At the time of implantation, Hoxa-10 mediates the progesterone-stimulated proliferation of uterine stromal cells. Hoxa-10 mutants express a stromal cell proliferation defect that is accompanied by quantitative or spatial alterations in the expression of two cyclin-dependent kinase inhibitor genes, p57 and p15. Hoxa-10 deficiency also leads to a severe local immunological disturbance, characterized by a polyclonal proliferation of T cells, that occurs in place of the normal progesterone-mediated immunosuppression in the periimplantation uterus.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 12554760   Authors: Yao MW,Lim H,Schust DJ,Choe SE,Farago A,Ding Y,Michaud S,Church GM,Maas RL
Exact source Table 2
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Source species Mus musculus
Contributed by Kevin Vogelsang (MSigDB Team)
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identifier namespace		 AFFY_MG_U74
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Version history 3.0: Renamed from YAO_P4_KO_VS_WT_DN

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