Human Gene Set: WIELAND_UP_BY_HBV_INFECTION


Standard name WIELAND_UP_BY_HBV_INFECTION
Systematic name M11620
Brief description Genes induced in the liver during hepatitis B (HBV) viral clearance in chimpanzees.
Full description or abstract Previous studies in hepatitis B virus (HBV)-infected humans and chimpanzees suggest that control of HBV infection involves the cells, effector functions, and molecular mediators of the immune response. The objective of the current study was to identify, in the liver of acutely HBV-infected chimpanzees, the spectrum of virus-induced and immune response-related genes that regulate the infection. The results demonstrate that HBV does not induce any genes during entry and expansion, suggesting it is a stealth virus early in the infection. In contrast, a large number of T cell-derived IFN-gamma-regulated genes are induced in the liver during viral clearance, reflecting the impact of an adaptive T cell response that inhibits viral replication and kills infected cells, thereby terminating the infection.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 15100412   Authors: Wieland S,Thimme R,Purcell RH,Chisari FV
Exact source Table 3S
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Source species Homo sapiens
Contributed by Kate Stafford (MSigDB Team)
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identifier namespace		 AFFY_HG_U133
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Version history 3.0: Renamed from WIELAND_HEPATITIS_B_INDUCED


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