Human Gene Set: WAKASUGI_HAVE_ZNF143_BINDING_SITES


Standard name WAKASUGI_HAVE_ZNF143_BINDING_SITES
Systematic name M9575
Brief description DNA repair genes whose promoters contain putative ZNF143 [GeneID=7702] binding sites.
Full description or abstract Zinc-finger protein 143 (ZNF143) is a human homolog of Xenopus transcriptional activator staf that is involved in selenocystyl tRNA transcription. We previously showed that ZNF143 expression is induced by treatment with DNA-damaging agents and that it preferentially binds to cisplatin-modified DNA. In this study, the potential function of ZNF143 was investigated. ZNF143 was overexpressed in cisplatin-resistant cells. ZNF143 knockdown in prostate cancer caused increased sensitivity for cisplatin, but not for oxaliplatin, etoposide and vincristine. We also showed that ZNF143 is associated with tumor suppressor gene product p73 but not with p53. p73 could stimulate the binding of ZNF143 to both ZNF143 binding site and cisplatin-modified DNA, and modulate the function of ZNF143. We provide a direct evidence that both Rad51 and flap endonuclease-1 are target genes of ZNF143 and overexpressed in cisplatin-resistant cells. Taken together, these experiments demonstrate that an interplay of ZNF143, p73 and ZNF143 target genes is involved in DNA repair gene expression and cisplatin resistance.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 17297437   Authors: Wakasugi T,Izumi H,Uchiumi T,Suzuki H,Arao T,Nishio K,Kohno K
Exact source Table 1S
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Source species Homo sapiens
Contributed by Leona Saunders (MSigDB Team)
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identifier namespace		 HUMAN_GENE_SYMBOL
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Version history 3.0: First introduced

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