Human Gene Set: VILLANUEVA_LIVER_CANCER_KRT19_DN


Standard name VILLANUEVA_LIVER_CANCER_KRT19_DN
Systematic name M373
Brief description Genes under-expressed in KRT19-positive [GeneID=3880] hepatocellular carcinoma (HCC).
Full description or abstract In approximately 70% of patients with hepatocellular carcinoma (HCC) treated by resection or ablation, disease recurs within 5 years. Although gene expression signatures have been associated with outcome, there is no method to predict recurrence based on combined clinical, pathology, and genomic data (from tumor and cirrhotic tissue). We evaluated gene expression signatures associated with outcome in a large cohort of patients with early stage (Barcelona-Clinic Liver Cancer 0/A), single-nodule HCC and heterogeneity of signatures within tumor tissues.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 21320499   Authors: Villanueva A,Hoshida Y,Battiston C,Tovar V,Sia D,Alsinet C,Cornella H,Liberzon A,Kobayashi M,Kumada H,Thung SN,Bruix J,Newell P,April C,Fan JB,Roayaie S,Mazzaferro V,Schwartz ME,Llovet JM
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Source species Homo sapiens
Contributed by Yujin Hoshida (Broad Institute)
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identifier namespace		 HUMAN_GENE_SYMBOL
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Version history 6.2: First introduced

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