Human Gene Set: VERHAAK_GLIOBLASTOMA_PRONEURAL


Standard name VERHAAK_GLIOBLASTOMA_PRONEURAL
Systematic name M2115
Brief description Genes correlated with proneural type of glioblastoma multiforme tumors.
Full description or abstract The Cancer Genome Atlas Network recently cataloged recurrent genomic abnormalities in glioblastoma multiforme (GBM). We describe a robust gene expression-based molecular classification of GBM into Proneural, Neural, Classical, and Mesenchymal subtypes and integrate multidimensional genomic data to establish patterns of somatic mutations and DNA copy number. Aberrations and gene expression of EGFR, NF1, and PDGFRA/IDH1 each define the Classical, Mesenchymal, and Proneural subtypes, respectively. Gene signatures of normal brain cell types show a strong relationship between subtypes and different neural lineages. Additionally, response to aggressive therapy differs by subtype, with the greatest benefit in the Classical subtype and no benefit in the Proneural subtype. We provide a framework that unifies transcriptomic and genomic dimensions for GBM molecular stratification with important implications for future studies.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 20129251   Authors: Verhaak RG,Hoadley KA,Purdom E,Wang V,Qi Y,Wilkerson MD,Miller CR,Ding L,Golub T,Mesirov JP,Alexe G,Lawrence M,O'Kelly M,Tamayo P,Weir BA,Gabriel S,Winckler W,Gupta S,Jakkula L,Feiler HS,Hodgson JG,James CD,Sarkaria JN,Brennan C,Kahn A,Spellman PT,Wilson RK,Speed TP,Gray JW,Meyerson M,Getz G,Perou CM,Hayes DN,Cancer Genome Atlas Research Network
Exact source TCGA_unified_CORE_ClaNC840.txt GO genes = PN
Related gene sets (show 3 additional gene sets from the source publication)

(show 260 gene sets from any of these authors)
External links https://tcga-data.nci.nih.gov/docs/publications/gbm_2010/
Filtered by similarity ?
Source species Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
Source platform or
identifier namespace		 HUMAN_GENE_SYMBOL
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 177 genes
Gene families ? Categorize these 177 genes by gene family
Show members (show 178 source identifiers mapped to 177 genes)
Version history 5.0: changed members and exact source


Creative Commons Attribution 4.0 International License (CC-BY-4.0)

The contents of this gene set are protected by copyright (c) 2004-2026 Broad Institute, Inc., Massachusetts Institute of Technology, and Regents of the University of California, subject to the terms and conditions of the Creative Commons Attribution 4.0 International License.

See the full MSigDB license terms here.