Human Gene Set: VANGURP_PANCREATIC_ALPHA_CELL


Standard name VANGURP_PANCREATIC_ALPHA_CELL
Systematic name M45029
Brief description Transcriptomic signature geneset for human pancreatic alpha cells derived from meta-analyzing multiple single cell RNAseq datasets
Full description or abstract Single cell RNAseq data from human pancreatic islets was downloaded from 7 previously published datasets. Pairwise differential expression was calculated between all islet cell types in each dataset, and results were integrated to compose a core list of ID genes for each cell types, organised primarily on the number of analyses a gene was detected in. A machine-learning based approach was used to threshold which genes were included in the final ID geneses, and these genesets were then cross validated in three independent datasets to demonstrate they outperformed previously published lists of ID genes.
Collection C8: Cell Type Signature
Source publication Pubmed 35440614   Authors: van Gurp L,Fodoulian L,Oropeza D,Furuyama K,Bru-Tari E,Vu AN,Kaddis JS,Rodríguez I,Thorel F,Herrera PL
Exact source Supplemental tables 11
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Source species Homo sapiens
Contributed by Leon van Gurp (Université de Genève)
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identifier namespace		 Human_Ensembl_Gene_ID
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Version history 2022.1.Hs: First Introduced.

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