Human Gene Set: UNTERMAN_PROGRESSIVE_VS_STABLE_IPF_CD8T_DN


Standard name UNTERMAN_PROGRESSIVE_VS_STABLE_IPF_CD8T_DN
Systematic name M48296
Brief description Genes downregulated in CD8 T-cells from Progressive Idiopathic Pulmonary Fibrosis Patients vs. Stable Non-Progressors
Full description or abstract Thirty-eight PBMC samples from 25 patients with IPF and 13 matched controls yielded 149,564 cells that segregated into 23 subpopulations. Classical monocytes were increased in progressive and stable IPF compared to controls (32.1%, 25.2%, 17.9%, respectively, p<0.05). Total lymphocytes were decreased in IPF vs controls, and in progressive vs stable IPF (52.6% vs 62.6%, p=0.035). Tregs were increased in progressive vs stable IPF (1.8% vs 1.1% of all PBMC, p=0.007), although not different than controls, and may be associated with decreased survival (P=0.009 in Kaplan-Meier analysis; P=0.069 after adjusting for age, sex, and baseline FVC). Flow cytometry analysis confirmed this finding in an independent cohort of IPF patients. Fraction of Tregs out of all T cells was also increased in two cohorts of lung scRNA-seq. CCL22 and CCL18, ligands for CCR4 and CCR8 Treg chemotaxis receptors, were increased in IPF. The single-cell atlas of the peripheral immune system in IPF, reveals an outcome-predictive increase in classical monocytes and Tregs, as well as evidence for a lung-blood immune recruitment axis involving CCL7 (for classical monocytes) and CCL18/CCL22 (for Tregs). (From Abstract)
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 38717443   Authors: Unterman A,Zhao AY,Neumark N,Schupp JC,Ahangari F,Cosme C Jr,Sharma P,Flint J,Stein Y,Ryu C,Ishikawa G,Sumida TS,Gomez JL,Herazo-Maya JD,Dela Cruz CS,Herzog EL,Kaminski N
Exact source table_e5_degs_progressivevsstable2, avg_LogFC<0, p_val_adg<0.05
Related gene sets (show 17 additional gene sets from the source publication)

(show 5 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Homo sapiens
Contributed by Anthony Castanza (MSigDB Team)
Source platform or
identifier namespace
HUMAN_GENE_SYMBOL
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 17 genes
Gene families ? Categorize these 17 genes by gene family
Show members (show 17 source identifiers mapped to 17 genes)
Version history 2024.1.Hs: First Introduced.

See MSigDB license terms here. Please note that certain gene sets have special access terms.