Human Gene Set: TONG_INTERACT_WITH_PTTG1


Standard name TONG_INTERACT_WITH_PTTG1
Systematic name M3844
Brief description Proteins that interact with PTTG1 [GeneID=9232], based on protein array.
Full description or abstract Pituitary tumor transforming gene 1 (PTTG1), a transforming gene highly expressed in several cancers, is a mammalian securin protein regulating both G1/S and G2/M phases. Using protein array screening, we showed PTTG1 interacting with Aurora kinase A (Aurora-A), and confirmed the interaction using co-immunoprecipitation, His-tagged pull-down assays and intracellular immunofluorescence colocalization. PTTG1 transfection into HCT116 cells prevented Aurora-A T288 autophosphorylation, inhibited phosphorylation of the histone H3 Aurora-A substrate and resulted in abnormally condensed chromatin. PTTG1-null cell proliferation was more sensitive to Aurora-A knock down and to Aurora kinase Inhibitor III treatment. The results indicate that PTTG1 and Aurora-A interact to regulate cellular responses to anti-neoplastic drugs. PTTG1 knockdown is therefore a potential approach to improve the efficacy of tumor Aurora kinase inhibitors.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 18663361   Authors: Tong Y,Ben-Shlomo A,Zhou C,Wawrowsky K,Melmed S
Exact source Table 1S
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Source species Homo sapiens
Contributed by Jessica Robertson (MSigDB Team)
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identifier namespace		 HUMAN_SEQ_ACCESSION
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Version history 3.0: First introduced


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