Human Gene Set: THEODOROU_MAMMARY_TUMORIGENESIS

For the Mouse gene set with the same name, see THEODOROU_MAMMARY_TUMORIGENESIS

Standard name THEODOROU_MAMMARY_TUMORIGENESIS
Systematic name M1291
Brief description Candidate mammary tumorigenesis genes from the common insertion sites (CIS) of MMTV virus that induced breast tumors in mice.
Full description or abstract We performed a high-throughput retroviral insertional mutagenesis screen in mouse mammary tumor virus (MMTV)-induced mammary tumors and identified 33 common insertion sites, of which 17 genes were previously not known to be associated with mammary cancer and 13 had not previously been linked to cancer in general. Although members of the Wnt and fibroblast growth factors (Fgf) families were frequently tagged, our exhaustive screening for MMTV insertion sites uncovered a new repertoire of candidate breast cancer oncogenes. We validated one of these genes, Rspo3, as an oncogene by overexpression in a p53-deficient mammary epithelial cell line. The human orthologs of the candidate oncogenes were frequently deregulated in human breast cancers and associated with several tumor parameters. Computational analysis of all MMTV-tagged genes uncovered specific gene families not previously associated with cancer and showed a significant overrepresentation of protein domains and signaling pathways mainly associated with development and growth factor signaling. Comparison of all tagged genes in MMTV and Moloney murine leukemia virus-induced malignancies showed that both viruses target mostly different genes that act predominantly in distinct pathways.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 17468756   Authors: Theodorou V,Kimm MA,Boer M,Wessels L,Theelen W,Jonkers J,Hilkens J
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Source species Mus musculus
Contributed by Leona Saunders (MSigDB Team)
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identifier namespace		 MOUSE_GENE_SYMBOL
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Version history 3.1: First introduced

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