Human Gene Set: SIRNA_EIF4GI_UP


Standard name SIRNA_EIF4GI_UP
Systematic name M2847
Brief description Genes up-regulated in MCF10A cells vs knockdown of EIF4G1 [GeneID=1981] gene by RNAi.
Full description or abstract eIF4GI Links Nutrient Sensing by mTOR to Cell Proliferation and Inhibition of Autophagy. Two sets of experiments are presented. First, overall transcriptome changes were determined for control or eIF4GI silenced cells. Next, mRNAs associated with polysomes were compared between control and eIF4GI silenced cells.
Collection C6: Oncogenic Signature
Source publication Pubmed 18426977   Authors: Ramírez-Valle F,Braunstein S,Zavadil J,Formenti SC,Schneider RJ
Exact source control vs RNAi KD eIFGI; top 100 genes (diff. of means)
Related gene sets (show 1 additional gene sets from the source publication)

(show 8 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Homo sapiens
Contributed by Pablo Tamayo (Broad Institute)
Source platform or
identifier namespace		 HUMAN_GENE_SYMBOL
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 95 genes
Gene families ? Categorize these 95 genes by gene family
Show members (show 100 source identifiers mapped to 95 genes)
Version history  

See MSigDB license terms here. Please note that certain gene sets have special access terms.