Standard name |
SHARMA_ASTROCYTOMA_WITH_NF1_SYNDROM |
Systematic name |
M216 |
Brief description |
Genes up-regulated in pilocytic astrocytoma (PA) samples from patients with type 1 neurofibromatosis syndrom (NF1) compared to the PA tumors from non-NF1 patients. |
Full description or abstract |
Pilocytic astrocytomas (PAs) are the most common glioma in children. Whereas many PAs are slow-growing or clinically indolent, others exhibit more aggressive features with tumor recurrence and death. To identify genetic signatures that might predict PA clinical behavior, we did gene expression profiling on 41 primary PAs arising sporadically and in patients with neurofibromatosis type 1 (NF1). Whereas no expression signature was found that could discriminate clinically aggressive or recurrent tumors from more indolent cases, PAs arising in patients with NF1 did exhibit a unique gene expression pattern. In addition, we identified a gene expression signature that stratified PAs by location (supratentorial versus infratentorial). Lastly, we also identified a gene expression pattern common to PAs and normal mouse astrocytes and neural stem cells from these distinct brain regions as well as a gene expression pattern shared between PAs and another human glial tumor (ependymoma) arising supratentorially compared with those originating in the posterior fossa. These results suggest that glial tumors share an intrinsic, lineage-specific molecular signature that reflects the brain region in which their nonmalignant predecessors originated. |
Collection |
C2: Curated CGP: Chemical and Genetic Perturbations |
Source publication |
Pubmed 17283119 Authors: Sharma MK,Mansur DB,Reifenberger G,Perry A,Leonard JR,Aldape KD,Albin MG,Emnett RJ,Loeser S,Watson MA,Nagarajan R,Gutmann DH |
Exact source |
Fig. 2A |
Related gene sets |
(show 2 additional gene sets from the source publication)
(show 24 gene sets from the same authors)
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External links |
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Filtered by similarity ?
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Source species |
Homo sapiens |
Contributed by |
Jessica Robertson (MSigDB Team) |
Source platform or identifier namespace |
AFFY_HG_U133 |
Dataset references |
(show 1 datasets)
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GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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these 5 genes
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Gene families ? |
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5 genes by gene family
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Show members |
(show 13 source identifiers mapped to 5 genes)
Source Id |
NCBI (Entrez) Gene Id |
Gene Symbol |
Gene Description |
1556202_at |
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1556203_a_at |
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1556352_at |
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1566624_at |
6507 |
SLC1A3 |
solute carrier family 1 member 3 [Sou... |
1566825_at |
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205200_at |
7123 |
CLEC3B |
C-type lectin domain family 3 member ... |
221211_s_at |
56911 |
MAP3K7CL |
MAP3K7 C-terminal like [Source:HGNC S... |
234871_at |
84059 |
ADGRV1 |
adhesion G protein-coupled receptor V... |
237361_at |
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240665_at |
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240824_at |
79991 |
STN1 |
STN1 subunit of CST complex [Source:H... |
242652_at |
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242903_at |
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Version history |
2022.1.Hs: Reintroduced after previously being screened out by mapping thresholds.
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