Human Gene Set: SCHERER_PBMC_YF_VAX_AGE_18_40YO_ANYD_UP

Standard name

SCHERER_PBMC_YF_VAX_AGE_18_40YO_ANYD_UP

Systematic name

M41126

Brief description

Genes up-regulated in peripheral blood mononuclear cell in adults (18-40) after exposure to YF-Vax , time point anyD

Full description or abstract

Gene expression in human peripheral blood mononuclear cells was systematically evaluated following smallpox and yellow fever vaccination, and naturally occurring upper respiratory infection (URI). All three infections were characterized by the induction of many interferon stimulated genes, as well as enhanced expression of genes involved in proteolysis and antigen presentation. Vaccinia infection was also characterized by a distinct expression signature composed of up-regulation of monocyte response genes, with repression of genes expressed by B and T-cells. In contrast, the yellow fever host response was characterized by a suppression of ribosomal and translation factors, distinguishing this infection from vaccinia and URI. No significant URI-specific signature was observed, perhaps reflecting greater heterogeneity in the study population and etiological agents. Taken together, these data suggest that specific host gene expression signatures may be identified that distinguish one or a small number of virus agents.

Collection

C7: Immunologic Signature
VAX: HIPC Vaccine Response

Source publication

Pubmed 17651872 Authors: Scherer CA,Magness CL,Steiger KV,Poitinger ND,Caputo CM,Miner DG,Winokur PL,Klinzman D,McKee J,Pilar C,Ward PA,Gillham MH,Haulman NJ,Stapleton JT,Iadonato SP

Exact source

Table 4

Related gene sets

(show 14 additional gene sets from the source publication)