Human Gene Set: SCHERER_PBMC_YF_VAX_AGE_18_40YO_ANYD_DN


Standard name SCHERER_PBMC_YF_VAX_AGE_18_40YO_ANYD_DN
Systematic name M41119
Brief description Genes down-regulated in peripheral blood mononuclear cell in adults (18-40) after exposure to YF-Vax , time point anyD
Full description or abstract Gene expression in human peripheral blood mononuclear cells was systematically evaluated following smallpox and yellow fever vaccination, and naturally occurring upper respiratory infection (URI). All three infections were characterized by the induction of many interferon stimulated genes, as well as enhanced expression of genes involved in proteolysis and antigen presentation. Vaccinia infection was also characterized by a distinct expression signature composed of up-regulation of monocyte response genes, with repression of genes expressed by B and T-cells. In contrast, the yellow fever host response was characterized by a suppression of ribosomal and translation factors, distinguishing this infection from vaccinia and URI. No significant URI-specific signature was observed, perhaps reflecting greater heterogeneity in the study population and etiological agents. Taken together, these data suggest that specific host gene expression signatures may be identified that distinguish one or a small number of virus agents.
Collection C7: Immunologic Signature
      VAX: HIPC Vaccine Response
Source publication Pubmed 17651872   Authors: Scherer CA,Magness CL,Steiger KV,Poitinger ND,Caputo CM,Miner DG,Winokur PL,Klinzman D,McKee J,Pilar C,Ward PA,Gillham MH,Haulman NJ,Stapleton JT,Iadonato SP
Exact source Table 4
Related gene sets (show 14 additional gene sets from the source publication)
External links https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211276/table/T4/
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Source species Homo sapiens
Contributed by HIPC SIGNATURES (NIAID/HIPC SIGNATURES)
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identifier namespace		 HUMAN_GENE_SYMBOL
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