Human Gene Set: SCHERER_PBMC_YF_VAX_AGE_18_40YO_ANYD_DN
Standard name
SCHERER_PBMC_YF_VAX_AGE_18_40YO_ANYD_DN
Systematic name
M41119
Brief description
Genes down-regulated in peripheral blood mononuclear cell in adults (18-40) after exposure to YF-Vax , time point anyD
Full description or abstract
Gene expression in human peripheral blood mononuclear cells was systematically evaluated following smallpox and yellow fever vaccination, and naturally occurring upper respiratory infection (URI). All three infections were characterized by the induction of many interferon stimulated genes, as well as enhanced expression of genes involved in proteolysis and antigen presentation. Vaccinia infection was also characterized by a distinct expression signature composed of up-regulation of monocyte response genes, with repression of genes expressed by B and T-cells. In contrast, the yellow fever host response was characterized by a suppression of ribosomal and translation factors, distinguishing this infection from vaccinia and URI. No significant URI-specific signature was observed, perhaps reflecting greater heterogeneity in the study population and etiological agents. Taken together, these data suggest that specific host gene expression signatures may be identified that distinguish one or a small number of virus agents.
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