Human Gene Set: SANSOM_APC_TARGETS_DN


Standard name SANSOM_APC_TARGETS_DN
Systematic name M1432
Brief description Top genes down-regulated at day 5 of Cre-Lox induced APC [GeneID=324] knockout in the intestine.
Full description or abstract Although Apc is well characterized as a tumor-suppressor gene in the intestine, the precise mechanism of this suppression remains to be defined. Using a novel inducible Ahcre transgenic line in conjunction with a loxP-flanked Apc allele we, show that loss of Apc acutely activates Wnt signaling through the nuclear accumulation of beta-catenin. Coincidentally, it perturbs differentiation, migration, proliferation, and apoptosis, such that Apc-deficient cells maintain a crypt progenitor-like phenotype. Critically, for the first time we confirm a series of Wnt target molecules in an in vivo setting and also identify a series of new candidate targets within the same setting.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 15198980   Authors: Sansom OJ,Reed KR,Hayes AJ,Ireland H,Brinkmann H,Newton IP,Batlle E,Simon-Assmann P,Clevers H,Nathke IS,Clarke AR,Winton DJ
Exact source Table 1cS
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Source species Mus musculus
Contributed by Kevin Vogelsang (MSigDB Team)
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identifier namespace		 MOUSE_SEQ_ACCESSION
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Version history 3.1: First introduced

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