Human Gene Set: RODWELL_AGING_KIDNEY_NO_BLOOD_DN


Standard name RODWELL_AGING_KIDNEY_NO_BLOOD_DN
Systematic name M11837
Brief description Genes whose expression decreases with age in normal kidney, excluding those with higher expression in blood.
Full description or abstract In this study, we found 985 genes that change expression in the cortex and the medulla of the kidney with age. Some of the genes whose transcripts increase in abundance with age are known to be specifically expressed in immune cells, suggesting that immune surveillance or inflammation increases with age. The age-regulated genes show a similar aging profile in the cortex and the medulla, suggesting a common underlying mechanism for aging. Expression profiles of these age-regulated genes mark not only age, but also the relative health and physiology of the kidney in older individuals. Finally, the set of aging-regulated kidney genes suggests specific mechanisms and pathways that may play a role in kidney degeneration with age.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 15562319   Authors: Rodwell GE,Sonu R,Zahn JM,Lund J,Wilhelmy J,Wang L,Xiao W,Mindrinos M,Crane E,Segal E,Myers BD,Brooks JD,Davis RW,Higgins J,Owen AB,Kim SK
Exact source Table 5S: Fold change < -1
Related gene sets (show 3 additional gene sets from the source publication)

(show 93 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Homo sapiens
Contributed by John Newman (University of Washington)
Source platform or
identifier namespace		 AFFY_HG_U133
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 148 genes
Gene families ? Categorize these 148 genes by gene family
Show members (show 190 source identifiers mapped to 148 genes)
Version history 3.0: Renamed from AGEING_KIDNEY_SPECIFIC_DN

See MSigDB license terms here. Please note that certain gene sets have special access terms.