Human Gene Set: RB_P130_DN.V1_DN


Standard name RB_P130_DN.V1_DN
Systematic name M2803
Brief description Genes down-regulated in primary keratinocytes from RB1 and RBL2 [GeneID=5925] [GeneID=5934] skin specific knockout mice.
Full description or abstract The epidermal-specific ablation of Rb gene leads to increased proliferation, aberrant differentiation, and the disengagement of these processes in vivo and in vitro. These differences in phenotype are more severe with the loss of p107, demonstrating the functional compensation between pRb and p107. As p107 and p130 also exert overlapping functions in epidermis, we have generated Rb(F19/F19)K14cre;Rbl2-/- (pRb-;p130-) mice to analyze possible functional redundancies between pRb and p130. The epidermal phenotype was very similar between pRb- and pRb-;p130- mice, suggesting that pRb and p130 activities are not redundant in epidermis. Importantly, we can correlate the proliferation differences with specific changes in gene expression between pRb-, pRb-;p107- and pRb-;p130- primary keratinocytes using microarray analysis, and explain the phenotypes in the context of altered E2F expression and functionality. Our findings support a model in which the distinct retinoblastoma family members, in conjunction with E2F members, play a central role in regulating epidermal homeostasis through specific or overlapping activities.
Collection C6: Oncogenic Signature
Source publication Pubmed 17932948   Authors: Lara MF,García-Escudero R,Ruiz S,Santos M,Moral M,Martínez-Cruz AB,Segrelles C,Lorz C,Paramio JM
Exact source RB -/- & p130-/-; bottom 150 genes (diff. of means)
Related gene sets (show 5 additional gene sets from the source publication)

(show 6 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Mus musculus
Contributed by Pablo Tamayo (Broad Institute)
Source platform or
identifier namespace		 HUMAN_GENE_SYMBOL
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 136 genes
Gene families ? Categorize these 136 genes by gene family
Show members (show 150 source identifiers mapped to 136 genes)
Version history 7.1: Fixed RIKEN identifiers.

See MSigDB license terms here. Please note that certain gene sets have special access terms.