Human Gene Set: RATTENBACHER_BOUND_BY_CELF1


Standard name RATTENBACHER_BOUND_BY_CELF1
Systematic name M2505
Brief description Transcripts bound by CELF1 [GeneID=10658] in HeLa cells (cervical carcinoma).
Full description or abstract CUG-repeat binding protein 1 (CUGBP1) mediates selective mRNA decay by binding to GU-rich elements (GREs) containing the sequence UGUUUGUUUGU found in the 3' untranslated region (UTR) of short-lived transcripts. We used an anti-CUGBP1 antibody to immunoprecipitate CUGBP1 from HeLa cytoplasmic extracts and analyzed the associated transcripts using oligonucleotide microarrays. We identified 613 putative mRNA targets of CUGBP1 and found that the UGUUUGUUUGU GRE sequence and a GU-repeat sequence were both highly enriched in the 3' UTRs of these targets. We showed that CUGBP1 bound specifically to the GU-repeat sequence and that insertion of this sequence into the 3' UTR of a beta-globin reporter transcript conferred instability to the transcript. Based on these results, we redefined the GRE to include this GU-repeat sequence. Our results suggest that CUGBP1 coordinately regulates the mRNA decay of a network of transcripts involved in cell growth, cell motility, and apoptosis.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 20547756   Authors: Rattenbacher B,Beisang D,Wiesner DL,Jeschke JC,von Hohenberg M,St Louis-Vlasova IA,Bohjanen PR
Exact source Table 1S
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Source species Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
Source platform or
identifier namespace		 AFFY_HG_U133
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Version history 3.1: First introduced

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