Human Gene Set: PULVER_FOREY_PERTURB_ACCUMULATION_G1_S


Standard name PULVER_FOREY_PERTURB_ACCUMULATION_G1_S
Systematic name M49291
Brief description Genes whose depletion leads to accumulation of cells in G1/S (pVal < 0.05) in K562 Repogle et al., 2022 reanalyzed with Velocycle from Lederer et al., 2024
Full description or abstract Transcription regulation during the cell cycle is crucial for ensuring genes are expressed at the right time and in the correct amounts, coordinating key processes like DNA replication, mitosis, and cell division. In our study, "Evolutionarily Recent Transcription Factors Partake in Human Cell Cycle Regulation" (Pulver & Forey et al., 2024), we analyzed the impact of gene depletion on the cell cycle in K562 cells, These comprehensive data are now accessible for exploration and visualization via a user-friendly web resource.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 40555235   Authors: Pulver C,Forey R,Lederer AR,Begnis M,Rosspopoff O,Carlevaro-Fita J,Martins F,Planet E,Duc J,Raclot C,Offner S,Coudray A,Dorschel A,Trono D
Exact source TableS4_PerturbSeq.xlsx
Related gene sets (show 23 additional gene sets from the source publication)
External links https://tronoapps.epfl.ch/cycleQuest/
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Source species Homo sapiens
Contributed by Romain Forey (EPFL)
Source platform or
identifier namespace		 HUMAN_GENE_SYMBOL
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GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Version history 2025.1.Hs: First Introduced.


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