Human Gene Set: PTEN_DN.V2_UP


Standard name PTEN_DN.V2_UP
Systematic name M2759
Brief description Genes up-regulated in HCT116 cells (colon carcinoma) upon knockdown of PTEN [GeneID=5728] by RNAi.
Full description or abstract Two HCT116 PTEN+/+ cell lines (parental cells and a clone with random integration of the targeting vector) and three independently-derived HCT116 PTEN-/- cell lines were studied
Collection C6: Oncogenic Signature
Source publication Pubmed 17060456   Authors: Kim JS,Lee C,Bonifant CL,Ressom H,Waldman T
Exact source PTEN ko vs control; top 300 genes (diff. of means)
Related gene sets (show 3 additional gene sets from the source publication)

(show 16 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Homo sapiens
Contributed by Pablo Tamayo (Broad Institute)
Source platform or
identifier namespace		 HUMAN_GENE_SYMBOL
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 139 genes
Gene families ? Categorize these 139 genes by gene family
Show members (show 150 source identifiers mapped to 139 genes)
Version history  

See MSigDB license terms here. Please note that certain gene sets have special access terms.