Human Gene Set: NOTCH_DN.V1_DN


Standard name NOTCH_DN.V1_DN
Systematic name M2788
Brief description Genes down-regulated in MOLT4 cells (T-ALL) by DAPT [PubChem=16219261], an inhibitor of NOTCH signaling pathway.
Full description or abstract NOTCH signaling in T-ALL cell lines. Three independent cultures of the MOLT4 cell line before and 48 hours after addition of the gamma-secretase inhibitor DAPT (5 uM).
Collection C6: Oncogenic Signature
Source publication Pubmed 17560996   Authors: Dohda T,Maljukova A,Liu L,Heyman M,Grandér D,Brodin D,Sangfelt O,Lendahl U
Exact source Control vs DAPT; top 200 genes (diff. of means)
Related gene sets (show 1 additional gene sets from the source publication)

(show 1 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Homo sapiens
Contributed by Pablo Tamayo (Broad Institute)
Source platform or
identifier namespace		 HUMAN_GENE_SYMBOL
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 183 genes
Gene families ? Categorize these 183 genes by gene family
Show members (show 200 source identifiers mapped to 183 genes)
Version history  

See MSigDB license terms here. Please note that certain gene sets have special access terms.