Human Gene Set: NAKAMURA_LUNG_CANCER_DIFFERENTIATION_MARKERS


Standard name NAKAMURA_LUNG_CANCER_DIFFERENTIATION_MARKERS
Systematic name M13656
Brief description 14 candidate differentiation markers in lung adenocarcinoma cells, noncancerous lung cells and peripheral blood cells.
Full description or abstract To identify tumor markers and differentiation markers for lung adenocarcinoma (AdC), we analysed expression profiles of 14,500 genes against three cases of type II alveolar epithelial cells, bronchiolar epithelial cells, and bronchial epithelial cells, respectively, and 10 cases of AdC cells isolated by laser capture microdissection. Hierarchical clustering analysis indicated that AdC cells and noncancerous lung epithelial cells are significantly different in their expression profiles, and that different sets of differentiation markers are expressed among alveolar, bronchiolar and bronchial epithelial cells. Nine genes were identified as being highly expressed in AdC cells, but not expressed in noncancerous lung epithelial cells. Sixteen genes were identified as differentiation markers for lung epithelial cells. Real-time RT-PCR analysis of 45 lung AdC cases further revealed that expression of four tumor markers in AdC cells was significantly higher than that in noncancerous lung cells and that expression of ten differentiation markers was retained in a considerable fraction of lung AdC cases. Five tumor markers and seven differentiation markers were not expressed in peripheral blood cells. Similarities and differences in expression profiles between normal epithelial cells from different lung respiratory compartments and AdC cells demonstrated in this study will be informative for the molecular diagnosis of lung AdC.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 16491115   Authors: Nakamura N,Kobayashi K,Nakamoto M,Kohno T,Sasaki H,Matsuno Y,Yokota J
Exact source Table 4
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Source species Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
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identifier namespace		 HUMAN_GENE_SYMBOL
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Version history 3.0: First introduced

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