Human Gene Set: NADLER_OBESITY_UP

For the Mouse gene set with the same name, see NADLER_OBESITY_UP

Standard name NADLER_OBESITY_UP
Systematic name M1431
Brief description Genes up-regulated in adipose tissue from obese mouse strains compared to the lean ones.
Full description or abstract Obesity is strongly correlated with type 2 diabetes mellitus, a common disorder of glucose and lipid metabolism. Although adipocytes are critical in obesity, their role in diabetes has only recently been appreciated. We conducted studies by using DNA microarrays to identify differences in gene expression in adipose tissue from lean, obese, and obese-diabetic mice. The expression level of over 11,000 transcripts was analyzed, and 214 transcripts showed significant differences between lean and obese mice. Surprisingly, the expression of genes normally associated with adipocyte differentiation were down-regulated in obesity. Not all obese individuals will become diabetic; many remain normoglycemic despite profound obesity. Understanding the transition to obesity with concomitant diabetes will provide important clues to the pathogenesis of type 2 diabetes. Therefore, we examined the levels of gene expression in adipose tissue from five groups of obese mice with varying degrees of hyperglycemia, and we identified 88 genes whose expression strongly correlated with diabetes severity. This group included many genes that are known to be involved in signal transduction and energy metabolism as well as genes not previously examined in the context of diabetes. Our data show that a decrease in expression of genes normally involved in adipogenesis is associated with obesity, and we further identify genes important for subsequent development of type 2 diabetes mellitus.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 11027337   Authors: Nadler ST,Stoehr JP,Schueler KL,Tanimoto G,Yandell BS,Attie AD
Exact source Table 2
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Source species Mus musculus
Contributed by Kevin Vogelsang (MSigDB Team)
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identifier namespace		 AFFY_Mu11K
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Version history 3.1: First introduced

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