Human Gene Set: MEK_UP.V1_DN


Standard name MEK_UP.V1_DN
Systematic name M2724
Brief description Genes down-regulated in MCF-7 cells (breast cancer) positive for ESR1 [GeneID=2099] MCF-7 cells (breast cancer) stably over-expressing constitutively active MAP2K1 [GeneID=5604] gene.
Full description or abstract Profiling of MCF-7 cell lines stably overexpressing constitutively active MEK as a model of overexpressed growth factor signaling, as well as control vector transfected cells (coMCF-7).
Collection C6: Oncogenic Signature
Source publication Pubmed 16585219   Authors: Creighton CJ,Hilger AM,Murthy S,Rae JM,Chinnaiyan AM,El-Ashry D
Exact source MEK vs Controls; bottom 200 genes (diff. of means)
Related gene sets (show 9 additional gene sets from the source publication)

(show 26 gene sets from the same authors)
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Source species Homo sapiens
Contributed by Pablo Tamayo (Broad Institute)
Source platform or
identifier namespace		 HUMAN_GENE_SYMBOL
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