Human Gene Set: MEBARKI_HCC_PROGENITOR_WNT_DN_BLOCKED_BY_FZD8CRD


Standard name MEBARKI_HCC_PROGENITOR_WNT_DN_BLOCKED_BY_FZD8CRD
Systematic name M38989
Brief description Transcriptome of human HepaRG hepatocellular carcinoma liver progenitors in responses to a WNT3A-enriched microenvironment and dissection of pathways dependent on _-catenin and/or blocked by the SFRP-like Wnt inhibitor FZD8_CRD.
Full description or abstract Methods: Liver progenitor cells were incubated in a WNT-enriched microenvironment for 72hrs (200 ng/ml mouse recombinant purified Wnt3A from R&D Systems). Gene pathways dependent on downstream _-catenin were studied by _-catenin knockdown with specific siRNA. Gene pathways blocked by extracellular SFRP-like Wnt inhibitors were studied by co-incubating cells with recombinant purified FZD8_CRD (300 ng/ml, from R&D Systems). Independent culture experiments performed in triplicate include untreated cells or cells incubated with scrambled siRNA or with _-catenin-specific siRNA or with FZD8_CRD, alone or in combination with Wnt3A.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 27191501   Authors: Mebarki S,Désert R,Sulpice L,Sicard M,Desille M,Canal F,Dubois-Pot Schneider H,Bergeat D,Turlin B,Bellaud P,Lavergne E,Le Guével R,Corlu A,Perret C,Coulouarn C,Clément B,Musso O
Exact source Supplementary Table 3E, in Mebarki et al., Oncotarget (2016), 7: 39026 - 39043
Related gene sets (show 11 additional gene sets from the source publication)

(show 13 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Homo sapiens
Contributed by Orlando Musso (INSERM (Institut National de la Santé et de la Recherche Médicale), France.)
Source platform or
identifier namespace		 Human_AGILENT_Array
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 70 genes
Gene families ? Categorize these 70 genes by gene family
Show members (show 88 source identifiers mapped to 70 genes)
Version history  

See MSigDB license terms here. Please note that certain gene sets have special access terms.