Human Gene Set: MCBRYAN_PUBERTAL_BREAST_4_5WK_DN

For the Mouse gene set with the same name, see MCBRYAN_PUBERTAL_BREAST_4_5WK_DN

Standard name MCBRYAN_PUBERTAL_BREAST_4_5WK_DN
Systematic name M12428
Brief description Genes down-regulated during pubertal mammary gland development between week 4 and 5.
Full description or abstract Expression microarray analysis identified over 930 genes regulated during puberty in the mouse mammary gland. Most prominent were genes whose expression increased in parallel with pubertal development and remained high thereafter. Members of the Wnt, transforming growth factor-beta and oestrogen-signalling pathways were significantly overrepresented. Comparison to expression data from CITED1 knockout mice identified a subset of oestrogen-responsive genes displaying altered expression in the absence of CITED1. Included in this subset are stanniocalcin2 (Stc2) and amphiregulin (Areg). Chromatin immunoprecipitation revealed that ERalpha binds to oestrogen response elements in both the Stc2 and Areg genes in the mammary gland during puberty. Additionally, CITED1 and ERalpha localize to the same epithelial cells of the pubertal mammary gland, supporting a role for interaction of these two proteins during normal development. In a human breast cancer data set, expression of Stc2, Areg and CITED1 parallel that of ERalpha. Similar to ERalpha, CITED1 expression correlates with good outcome in breast cancer, implying that potential maintenance of the ERalpha-CITED1 co-regulated signalling pathway in breast tumours can indicate good prognosis.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 17486082   Authors: McBryan J,Howlin J,Kenny PA,Shioda T,Martin F
Exact source Table 1S: week 4 to 5 = D
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Source species Mus musculus
Contributed by Arthur Liberzon (MSigDB Team)
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identifier namespace		 AFFY_Mouse430
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Version history 3.0: First introduced

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