Human Gene Set: MANNE_COVID19_COMBINED_COHORT_VS_HEALTHY_DONOR_PLATELETS_DN


Standard name MANNE_COVID19_COMBINED_COHORT_VS_HEALTHY_DONOR_PLATELETS_DN
Systematic name M38981
Brief description Strongly downregulated genes from differential gene expression analysis of platelets from 10 combined ICU and Non-ICU COVID-19 patients and, for comparison, 5 healthy donors
Full description or abstract Thrombotic complications in patients with COVID-19 are common and contribute to organ failure and mortality. Patients with severe COVID-19 present with hemostatic abnormalities that mimic disseminated intravascular coagulopathy associated with sepsis with the major difference being increased risk of thrombosis rather than bleeding. However, whether SARS-CoV-2 infection alters platelet function to contribute to the pathophysiology of COVID-19 remains unknown. In this study, we report altered platelet gene expression and functional responses in patients infected with SARS-CoV-2.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 32573711   Authors: Manne BK,Denorme F,Middleton EA,Portier I,Rowley JW,Stubben C,Petrey AC,Tolley ND,Guo L,Cody M,Weyrich AS,Yost CC,Rondina MT,Campbell RA
Exact source Supplemental Table 4. Platelet differential gene expression analysis from COVID-19 patients. Genes with Log2(FC)<-2, pAdj<0.05.
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Source species Homo sapiens
Contributed by Anthony Castanza (MSigDB Team)
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identifier namespace		 Human_Ensembl_Gene_ID
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