Human Gene Set: MAHAJAN_RESPONSE_TO_IL1A_DN


Standard name MAHAJAN_RESPONSE_TO_IL1A_DN
Systematic name M12107
Brief description Genes down-regulated in corneal fibroblasts after treatment with IL1A [GeneID=3552].
Full description or abstract PURPOSE: To identify changes in gene expression in human corneal fibroblasts after exposure to interleukin-1alpha. METHODS: RNA was isolated from cultured human corneal fibroblasts after treatment with interleukin-1alpha and subjected to DNA microarray analysis. Changes in gene expression were determined by comparison with untreated cells in three independent experiments after a Bayesian statistical analysis of variance. RESULTS: Changes in gene expression were reproducibly observed in 165 genes representing previously identified and novel chemokines, matrix molecules, membrane receptors, angiogenic mediators, and transcription factors that correlated with pathophysiological responses to inflammation. Dramatic increases in gene expression were observed with exodus-1 (CCL20), MMP-12, and RhoA. CONCLUSIONS: DNA microarray analysis of the corneal fibroblast response to interleukin-1alpha provides important insight into modeling changes in gene expression and suggests novel therapeutic targets for the control of corneal inflammation.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 12091409   Authors: Mahajan VB,Wei C,McDonnell PJ 3rd
Exact source Table 1,2: Change <= -2
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Source species Homo sapiens
Contributed by John Newman (University of Washington)
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identifier namespace		 HUMAN_SEQ_ACCESSION
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Version history 3.0: Renamed from IL1_CORNEA_DN

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