Human Gene Set: LI_WILMS_TUMOR_VS_FETAL_KIDNEY_2_DN


Standard name LI_WILMS_TUMOR_VS_FETAL_KIDNEY_2_DN
Systematic name M1246
Brief description Genes down-regulated in Wilm's tumor vs fetal kidney.
Full description or abstract Anaplasia (unfavorable histology) is associated with therapy resistance and poor prognosis of Wilms tumor, but the molecular basis for this phenotype is unclear. Here, we used a cDNA array with 9240 clones relevant to cancer biology and/or kidney development to examine the expression profiles of 54 Wilms tumors, five normal kidneys and fetal kidney. By linking genes differentially expressed between fetal kidney and Wilms tumors to kidney morphogenesis, we found that genes expressed at a higher level in Wilms tumors tend to be expressed more in uninduced metanephrogenic mesenchyme or blastema than in their differentiated structures. Conversely, genes expressed at a lower level in Wilms tumors tend to be expressed less in uninduced metanephrogenic mesenchyme or blastema. We also identified 97 clones representing 76 Unigenes or unclustered ESTs that clearly separate anaplastic Wilms tumors from tumors with favorable histology. Genes in this set provide insight into the nature of the abnormal nuclear morphology of anaplastic tumors and may facilitate identification of molecular targets to improve their responsiveness to treatment.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 15531917   Authors: Li W,Kessler P,Williams BR
Exact source Table 1S: change < 0
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Source species Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
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identifier namespace		 HUMAN_SEQ_ACCESSION
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