Human Gene Set: LI_ESTROGENE_BIDIRECTIONAL_E2_RESPONSE


Standard name LI_ESTROGENE_BIDIRECTIONAL_E2_RESPONSE
Systematic name M48225
Brief description Bidirectional estrogen regulated genes in breast cancer cell lines merged from 146 NGS datasets-based comparisons (present in the top 10% of both upregulated and downregulated targets in at least 10% of comparisons).
Full description or abstract As one of the most successful cancer therapeutic targets, estrogen receptor-alpha (ER/ESR1) has been extensively studied over the past few decades. Sequencing technological advances have enabled genome-wide analysis of ER action. However, comparison of individual studies is limited by different experimental designs, and few meta-analyses are available. Here, by ingesting large amount of E2-related transcriptomic data sets in breast cancer cell lines, we identified gene expression changes across 66 RNA-seq and 80 microarray experiments based upon the E2-induced fold change in gene expression. By examining the plasticity of the directionality of estrogen response, we found the correlation of upregulation and downregulation of all 12,429 genes in the merged data collection revealed a strong nonlinear negative association, showing that most genes exhibited a single monodirectional regulation by estradiol. Unexpectedly, we also identified a subset of bidirectionally regulated genes (n = 101) that are present in the top 10% of both upregulated and downregulated targets and in at least 10% of comparisons. Their divergent regulation was not associated with specific experimental conditions such as E2 treatment duration or cell line context
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 37272757   Authors: Li Z,Li T,Yates ME,Wu Y,Ferber A,Chen L,Brown DD,Carroll JS,Sikora MJ,Tseng GC,Oesterreich S,Lee AV
Exact source Supplementary Table S10: EstroGene temporal, contextual and directional signatures. Detailed GEO IDs of all the datasets used can be found in Supplementary Table S1 Inventory of EstroGene Database of the publication.
Related gene sets (show 14 additional gene sets from the source publication)

(show 38 gene sets from the same authors)
External links https://estrogene.org/
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Source species Homo sapiens
Contributed by Zheqi Li (University of Pittsburgh)
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identifier namespace		 HUMAN_GENE_SYMBOL
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Version history 2024.1.Hs: First Introduced.

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