Human Gene Set: LIN_NPAS4_TARGETS_DN

For the Mouse gene set with the same name, see LIN_NPAS4_TARGETS_DN

Standard name LIN_NPAS4_TARGETS_DN
Systematic name M7327
Brief description Genes down-regulated in neurons after NPAS4 [GeneID=266743] knockdown by RNAi.
Full description or abstract Neuronal activity regulates the development and maturation of excitatory and inhibitory synapses in the mammalian brain. Several recent studies have identified signalling networks within neurons that control excitatory synapse development. However, less is known about the molecular mechanisms that regulate the activity-dependent development of GABA (gamma-aminobutyric acid)-releasing inhibitory synapses. Here we report the identification of a transcription factor, Npas4, that plays a role in the development of inhibitory synapses by regulating the expression of activity-dependent genes, which in turn control the number of GABA-releasing synapses that form on excitatory neurons. These findings demonstrate that the activity-dependent gene program regulates inhibitory synapse development, and suggest a new role for this program in controlling the homeostatic balance between synaptic excitation and inhibition.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 18815592   Authors: Lin Y,Bloodgood BL,Hauser JL,Lapan AD,Koon AC,Kim TK,Hu LS,Malik AN,Greenberg ME
Exact source Table 1S: D = Down-regulated
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Source species Mus musculus
Contributed by Jessica Robertson (MSigDB Team)
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identifier namespace		 AFFY_Mouse430
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Version history 3.0: First introduced

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