Human Gene Set: LIN_APC_TARGETS


Standard name LIN_APC_TARGETS
Systematic name M17434
Brief description Genes up-regulated by forced expression of APC [GeneID=324] in the APC-deficient SW480 cell line (colon cancer).
Full description or abstract To elucidate the molecular mechanism of colorectal carcinogenesis, we have been attempting to isolate genes involved in the beta-catenin/T-cell factor pathway. In the experiments reported here, analysis by cDNA microarray indicated that AF17, a fusion partner of the MLL gene in acute leukemias with t(11;17)(q23;q21), was transactivated according to accumulation of beta-catenin. Expression of AF17 was significantly enhanced in 8 of the 12 colorectal cancer tissues examined. Introduction of a plasmid designed to express AF17 stimulated growth of NIH3T3 cells, and fluorescence-activated cell sorter analysis indicated that the AF17 regulation of cell-cycle progression was occurring mainly at the G(2)-M transition. Our results suggest that the AF17 gene product is likely to be involved in the beta-catenin-T-cell factor/lymphoid enhancer factor signaling pathway and to function as a growth-promoting, oncogenic protein. These findings should aid development of new strategies for diagnosis, treatment, and prevention of colon cancers and acute leukemias by clarifying the pathogenesis of these conditions.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 11522623   Authors: Lin YM,Ono K,Satoh S,Ishiguro H,Fujita M,Miwa N,Tanaka T,Tsunoda T,Yang KC,Nakamura Y,Furukawa Y
Exact source Table 1
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Source species Homo sapiens
Contributed by Yujin Hoshida (Broad Institute)
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identifier namespace		 HUMAN_SEQ_ACCESSION
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Version history 3.0: Renamed from LIN_WNT_UP

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